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KMID : 0371319710130090029
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Journal of the Korean Surgical Society
1971 Volume.13 No. 9 p.29 ~ p.35
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Hypercalcemia and Gastric Secretion in Man
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Abstract
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To study the effect of serum calcium level upon gastric secretion, the volume and acidity of
gastric secretion were measured every half hour during calcium infusion in man. Calcium(15㎎/
㎏ of body weight in a liter of physiological saline solution) was infused over 4 hours period into
the non-ulcer group (10 cases) and the duodenal ulcer group (5 cases), while a liter of physiolo
gical saline solution into the control group ( 6 cases). Histamine test to the non-ulcer and duodenal
ulcer group was done for maximal gastric secretion.
The result obtained were as follos;
1. The significant incremenf of serim calcium level was developed one and half hours after
beginning of the calcium infusion.
2. The volume and acid concentration of gastric secretion were significantly increased from one
hout later of induced hypercalcemia.
3. The maximal volume of calcium stimulated gastric secretion was 48.7±16.3% in non-ulcer
group and 51.6±11.0% in duodenal ulcer group of the greatest volume of gastric juice following
histamine injection.
4. In non-ulcer group, the maximal acid secretion following administration of calcium was 75.5
±11.2% (in total acid) and 76.9±20.5%(in free acid)of that by histamine, while in duodenal
ulcer group, 67.8±5.9%(in total acid) and 66.2±11.4%(in free acid).
5. The increased acidity of gastric secretion persisted for two or more hours after completion of
the calcium infusion and the increased volume of gastric juice persisted for one or more hour in
both groups.
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